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16/05/2017 Wobst HJ, Delsing L, Brandon NJ, Moss SJ Truncation of the TAR DNA-binding protein 43 is not a prerequisite for cytoplasmic relocalization, and is suppressed by caspase inhibition and by introduction of the A90V sequence variant PLoS One N/A Link
12/01/2017 Wobst H, Wesolowski S, Delsing L, Jacobsen S, Deeb T, Dunlop J, Brandon NJ, Moss S Cytoplasmic relocalization of TAR DNA-binding protein 43 is not sufficient to reproduce cellular pathologies associated with ALS in vitro Frontiers in Molecular Neuroscience N/A Link
26/03/2018 Cross A, Anthenelli R, Li X Metabotropic glutamate receptor 2/3 as targets for treating nicotine addiction Biological Psychiatry 947–954 No Link
13/04/2018 Wright C, Ross DA, Weinberger D Small RNAs may answer big questions in mental illness Biological Psychiatry e1–e3 Link
28/02/2018 Fan J, Zhao RQ, Parro C, Zhao W, Chou H-Y, Robert J, Deeb T, Barichievy S, Brandon NJ, Wood MW, Kulic I, Wellington CL Small molecule inducers of ABCA1 and apoE that act though indirect activation of the LXR pathway Journal of Lipid Research 830-842 Link
28/11/2017 Agez M, Schultz P, Medina I, Baker DJ, Burnham MP, Cardarelli R, Conway LC, Garnier K, Geschwindner S, Gunnarsson A, McCall EJ, Frechart A, Audebert S, Deeb T, Moss S, Brandon N, Wang Q, Dekker N, Jawhari A Molecular architecture of potassium chloride co-transporter KCC2 Scientific Reports 1038 Link
04/10/2017 Johansson P, Kaspersson K, Gurrell I, Bäck E, Eketjäll S, Scott C, Ceber G, Thorne P, McKenzie M, Beaton H, Davey P, Kolmodin K, Holenz J, Duggan M, Budd Häberlein S, Bürli R Toward β-secretase-1 inhibitors with improved isoform selectivity Journal of Medicinal Chemistry 3491–3502 Link
16/04/2018 Johansson P, Kaspersson K, Gurrell I, Bäck E, Eketjäll E, Scott C, Cebers G, Thorne P, McKenzie M, Beaton H, Davey P, Kolmodin K, Holenz J, Duggan M, Häberlein SB, Bürli RW Toward β-secretase-1 inhibitors with improved isoform selectivity Journal of Medicinal Chemistry 3491–3502 Link
08/11/2017 Witten MR, Wissler L, Snow M, Geschwindner S, Read JA, Brandon NJ, Nairn AC, Lombroso PJ, Käck H, Ellman JA X-ray characterization and structure-based optimization of striatal-enriched protein tyrosine phosphatase inhibitors Journal of Medicinal Chemistry 9299–9319 Link
20/07/2017 Yalla K, Elliott C, Day JP, Findlay J, Barratt S, Hughes ZA, Wilson L, Whiteley E, Popiolek M, Li Y, Dunlop J, Killick R, Adams DR, Brandon NJ, Houslay MD, Hao B, Baillie GS FBXW7 regulates DISC1 stability via the ubiquitin-proteosome system Molecular Psychiatry 1278–1286 Link
10/01/2017 O’Brien WE, Shaw DM, Cho HP, Cross AJ, Wesolowski SS, Felts AS, Bergare J, Elmore CS, Lindsley CW, Niswender CM, Conn PJ Differential pharmacology and binding of mGlu2 allosteric modulators Molecular Pharmacology 526-540 Link
30/01/2018 Wassmer T, Evans L, Fraser G, Smith J, Perkinton M, Billinton A, Livesey FJ Extracellular monomeric and aggregated tau efficiently enter human neurons through overlapping but distinct pathways Cell Reports N/A Link
01/11/2017 Nicol LSC, Thornton P, Hatcher JP, Glover CP, Webster CI, Burrell M, Jones CA, Sleeman M, Billinton A, Chessell I Central inhibition of granulocyte macrophage colony-stimulating factor is analgesic in experimental neuropathic pain Pain 550–559 Link
16/06/2017 Conway LC, Cardarelli RA, Moore YE, Jones K, McWilliams LJ, Baker D, Burnham MP, Bürli RW, Wang Q, Brandon NJ, Moss SJ, Deeb TZ N-ethylmaleimide increases KCC2 activity by modulating transporter phosphorylation Gordon Research Conference - Inhibition in the CNS 2017 N/A Link
24/04/2017 Vargas-Caballero M, Denk F, Wobst HJ, Arch E, Pegasiou CM, Oliver PL, Shipton OA, Paulsen O, Wade-Martins R Wild-type, but not mutant N296H, human tau restores Aβ-mediated inhibition of LTP in Tau−/− mice Frontiers in Neuroscience N/A Link
27/08/2017 Burli R β-Secretase inhibitors as a therapy for Alzheimer’s disease – where are we now? European Federation for Medicinal Chemistry - 7th Advances in Synthetic and Medicinal Chemistry N/A Link
24/10/2017 Tarr J, Wood M, Noetzel M, Melancon B, Luscombe V, Rodriguez A, Byers F, Chang S, Cho H, Engers D, Jones C, Niswender C, Wood M, Brandon N, Duggan M, Conn J, Bridges T, Lindsley C Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides Bioorganic & Medicinal Chemistry Letters 5179-5184 Link
01/10/2017 Chauhan R, Chen K, Kent BA, Crowther DC Central and peripheral circadian clocks and their role in Alzheimer’s disease Disease Models & Mechanisms N/A Link
23/10/2017 Barbour C, Kosa P, Komori M, Tanigawa M, Masvekar R, Wu T, Johnson K, Douvaras P, Fossati V, Herbst R, Wang Y, Tan K, Greenwood M, Bielekova B Molecular-based diagnosis of Multiple Sclerosis and its progressive stage Annals of Neurology N/A Link
10/08/2017 Moore Y, Kelley M, Brandon N, Deeb T, Moss S Seizing control of KCC2: A new therapeutic target for epilepsy Trends in Neurosciences 555–571 Link
01/11/2017 Conway L, Cardarelli R, Moore Y, Jones K, McWilliams L, Baker D, Burnham M, Bürli R, Wang Q, Brandon N, Moss S, Deeb T N-ethylmaleimide increases KCC2 activity by modulating transporter phosphorylation The Journal of Biological Chemistry 292 Link
02/03/2017 Pedersen J, Khan EK, Bergstrom CAS, Palm J, Hoogstraate J, Artursson P Substrate and method dependent inhibition of three ABC-transporters (MDR1, BCRP, and MRP2) European Journal of Pharmaceutical Sciences 70-76 Link
06/05/2017 Tarr J, Wood M, Noetzel M, Bertron J, Weiner R, Luscombe V, Rodriguez A, Lamsal A, Byers F, Chang S, Plumley H, Jones C, Niswender C, Wood M, Brandon N, Duggan M, Conn J, Bridges T, Lindsley C Challenges in development of an M4 PAM preclinical candidate: The discovery, SAR, and in vivo characterization of a series of 3-aminoazetidine-derived amides Bioorganic & Medicinal Chemistry Letters 2990-2995 Link
16/10/2017 Mukherjee J, Cardarelli R, Cantaut-Belarif Y, Deeb T, Srivastava D, Pangalos M, Triller A, Maguire, Brandon N, Moss S Estradiol modulates the efficacy of fast synaptic inhibition by decreasing the dwell time of GABAA receptors at inhibitory synapses Proceedings of the National Academy of Sciences of the United States of America 8424 Link
13/03/2017 Sweeney P, Park H, Baumann M, Dunlop J, Frydman J, Kopito R, McCampbell A, Leblanc G, Venkateswaran A, Nurmi A, Hodgson R Protein misfolding in neurodegenerative diseases: implications and strategies Translational Neurodegeneration 6:6 Link
13/04/2017 Melancon BJ, Wood MR, Noetzel MJ, Nance KD, Engelber EM, Han C, Lamsal A, Chang S, Cho HP, Byers FW, Bubser M, Jones CK, Niswender CM, Wood MW, Engers DW, Wu D, Brandon NJ, Duggan ME, Conn J, Bridges TM, Lindsley CW Optimization of M4 positive allosteric modulators (PAMs): The discovery of VU0476406, a non-human primate in vivo tool compound for translational pharmacology Bioorganic & Medicinal Chemistry Letters 2296-2301 Link
23/03/2017 Dudley A, Godwood A The Importance of Teamwork & Collaboration in Drug Development University Technical College Cambridge 96 Link
09/03/2017 Law B, Perkinton M, Williams R Utility of an APP-GAL4 reporter assay to identify early neuronal responses to beta-gamma-secretase APP processing reveals impaired AKT signaling and upregulation of FOXO3a Molecular Neurodegeneration 673-68 Link
17/07/2017 Gould RW, Grannan MD, Gunter BW, Ball J, Bubser M, Bridges TM, Wess J, Wood MW, Brandon NJ, Duggan ME, Niswender CM, Lindsley CW, Conn PJ, Jones CK Cognitive enhancement and antipsychotic-like activity following repeated dosing with the selective M4 PAM VU0467154 Neuropharmacology 492-502 Link
30/08/2017 Thornton P, Sevalle J, Deery MJ, Fraser G, Zhou Y, Ståhl S, Franssen EH, Dodd RB, Qamar S, Gomez Perez-Nievas B, Nicol LSC, Eketjäll S, Revell J, Jones C, Billinton A, St George-Hyslop PH, Chessell I, Crowther DC TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer’s disease-associated H157Y variant EMBO Molecular Medicine 1366-1378 Link
17/02/2017 Kang J, Chadchankar J, Vien T, Mighdoll M, Hyde T, Mather R, Deeb T, Pangalos M, Brandon N, Moss S, Dunlop J Deficits in the activity of presynaptic γ-Aminobutyric acid type B receptors contribute to altered neuronal excitability in Fragile X Syndrome The Journal of Biological Chemistry 6621-6632 Link
31/01/2017 Dahoun T, Trossbach S, Brandon N, Korth C, Howes O The impact of disrupted-in-Schizophrenia 1 (DISC1) on the dopaminergic system: a systematic review Translational Psychiatry e1015 Link
20/12/2016 Acri J, Cross A, Skolnick P From bench to bedside: mGluR2 positive allosteric modulators as medications to treat substance use disorders Psychopharmacology 1347–1355 Link
20/09/2017 Shi Y, Yamada K, Liddelow S, Smith S, Zhao L, Luo W, Tsai R, Spina S, Grinberg L, Rojas J, Gallardo G, Wang K, Roh J, Robinson G, Finn MB, Jiang H, Sullivan P Baufeld C, Wood M, Sutphen C, McCue L, Xiong C, Del-Aguila J, Morris J, Cruchaga C, Alzheimer’s Disease Neuroimaging Initiative, Fagan A, Miller B, Boxer A, Seely W, Butovsky O, Barres B, Paul S, Holtzman D ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy Nature 549 Link
20/05/2017 Assmann JC, Müller K, Wenzel J, Walther T, Brands J, Thornton P, Allan SM, Schwaninger M Isolation and cultivation of primary brain endothelial cells from adult mice Bio-protocol e2294 Link
24/12/2016 Jucaite A, Cselenyi Z, Lappalainen J, McCarthy DJ, Lee CM, Nyberg S, Varnas K, Stenkrona P, Halldin C, Cross A, Farde L GABA receptor occupancy by subtype selective GABA modulators: PET studies in humans Psychopharmacology 707–716 Link
25/11/2016 Thornton P, Sevalle J, Deery M, Fraser G, Zhou Y, Ståhl S, Franssen E, Burguillos M, Dodd R, Qamar S, Gomez Perez-Nievas B, Nicol LSC, Eketjäll S, Revell J, Jones, C, Billinton A, St.George-Hyslop P, Chessell I, Crowther DC TREM2 shedding by cleavage at the His157-Ser158 bond is accelerated in the Alzheimer’s disease-linked His157Tyr variant The Journal of Biological Chemistry 1366-1378 Link
13/06/2017 Wood MW, Martino G, Coupal M, Lindberg M, Schroeder P, Santhakumar V, Valiquette M, Sandin J, Widzowski D, Laird J Broad analgesic activity of a novel, selective M1 agonist Neuropharmacology 233-241 Link
16/03/2017 Croft C, Wade M, Kurbatskaya K, Mastrandreas P, Hughes M, Phillips E, Pooler A, Perkinton M, Hanger D, Noble W Membrane association and release of wild-type and pathological tau from organotypic brain slice cultures Cell Death & Disease e2671 Link
16/12/2016 Wood M, Noetzel M, Melancon B, Poslusney M, Nance K, Hurtado M, Luscombe V, Weiner R, Rodriguez A, Lamsal A, Chang S, Engers D, Niswender C, Jones C, Brandon N, Wood M W, Duggan M, Conn J, Bridges T, Lindsley C Discovery of VU0467485/AZ13713945: An M4 positive allosteric modulator evaluated as a preclinical candidate for the treatment of Schizophrenia ACS Medicinal Chemistry Letters 233–238 Link
22/03/2017 Radojčić M, Thudium C, Henriksen K, Tan K, Karlsten R, Dudley A, Chessell I, Karsdal M, Bay-Jensen A-C, Crema M, Guermazi A Biomarker of extracellular matrix remodelling C1M and proinflammatory cytokine interleukin 6 are related to synovitis and pain in end-stage knee osteoarthritis patients Pain 1254–1263 Link
30/11/2016 Wood MR, Noetzel MJ, Poslusney MS, Melancon BJ, Tarr JC, Lamsal A, Chang S, Luscombe VB, Weiner RL, Cho HP, Bubser M, Jones CK, Niswender CM, Wood MW, Engers DW, Brandon NJ, Duggan ME, Conn J, Bridges TM, Lindsley CW Challenges in the development of an M4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs Bioorganic & Medicinal Chemistry Letters 171-175 Link
19/12/2016 Webster CI, Hatcher J, Burrell M, Thom G, Thornton P, Gurrell I, Chessell I Enhanced delivery of IL-1 receptor antagonist to the CNS as a novel anti-TfR-IL-1RA fusion reverses neuropathic mechanical hypersensitivity Pain 660–668 No Link
26/04/2017 Cheng RKY, Fiez-Vandal C, Schlenker O, Edman K, Aggeler B, Brown D, Brown G, Cooke R, Dumelin C, Dore AS, Geschwindner S, Grebner C, Hermansson N-O, Jazayeri A, Johansson P, Leong L, Prihandoko R, Rappas M, SOutter H, Snijder A, Sundstrom L, Tehan B, Thornton P, Troast D, Wiggin G, Zhukov A, Marshall FH, Dekker N Structural insight into allosteric modulation of protease-activated receptor 2 Nature 112-115 Link
21/09/2017 Schuelke J, Brandon N Current understanding of PDE10A in the modulation of basal ganglia circuitry Book 1 Link
02/11/2016 Sanacora, Johnson, Khan, Atkinson, Riesenberg, Schronen, Burke, Zajecka, Barra, Su, Posener, Bui, Quirk, Piser, Mathew, Pathak Adjunctive lanicemine (AZD6765) in patients with major depressive disorder and history of inadequate response to antidepressants: a randomized, placebo-controlled study Neuropsychopharmacology 844–853 Link
05/03/2018 Kuczynski EA, Vermeulen PB, Pezzella F, Kerbel RS, Reynolds AR Vessel co-option in cancer: mechanisms and clinical implications Nature Reviews Clinical Oncology 15 Link
10/01/2018 Clinical bioavailability of the novel BACE1 inhibitor lanabecestat (AZD3293): Assessment of tablet formulations versus an oral solution and the impact of gastric pH on pharmacokinetics No Link
19/12/2017 Law BM, Guest AL, Pullen MWJ, Perkinton MS, Williams RJ Increased Foxo3a Nuclear Translocation and Activity is an Early Neuronal Response to βγ-Secretase-Mediated Processing of the Amyloid-β Protein Precursor: Utility of an AβPP-GAL4 Reporter Assay Journal of Alzheimer's Disease 673-688 Link
21/11/2017 Cross A, Anthenelli R, Li X Metabotropic glutamate receptors 2 and 3 as targets for treating nicotine addiction Biological Psychiatry 947–954 No Link
13/04/2018 Wright C, Ross DA, Weinberger D Small RNAs may answer big questions in mental illness Biological Psychiatry e1–e3 Link
19/03/2018 Fan J, Zhao RQ, Parro C, Zhao W, Chou H-Y, Robert J, Deeb T, Barichievy S, Brandon NJ, Wood MW, Kulic I, Wellington CL Small molecule inducers of ABCA1 and apoE that act though indirect activation of the LXR pathway Journal of Lipid Research 830-842 Link
21/03/2018 Johansson P, Kaspersson K, Gurrell I, Bäck E, Eketjäll E, Scott C, Cebers G, Thorne P, McKenzie M, Beaton H, Davey P, Kolmodin K, Holenz J, Duggan M, Häberlein SB, Bürli RW Toward β-secretase-1 inhibitors with improved isoform selectivity Journal of Medicinal Chemistry 3491–3502 Link
20/03/2018 Yalla K, Elliott C, Day JP, Findlay J, Barratt S, Hughes ZA, Wilson L, Whiteley E, Popiolek M, Li Y, Dunlop J, Killick R, Adams DR, Brandon NJ, Houslay MD, Hao B, Baillie GS FBXW7 regulates DISC1 stability via the ubiquitin-proteosome system Molecular Psychiatry 1278–1286 Link
21/05/2018 O’Brien WE, Shaw DM, Cho HP, Cross AJ, Wesolowski SS, Felts AS, Bergare J, Elmore CS, Lindsley CW, Niswender CM, Conn PJ Differential pharmacology and binding of mGlu2 allosteric modulators Molecular Pharmacology 526-540 Link
21/02/2018 Thom G, Hatcher J, Hearn A, Paterson J, Rodrigo N, Beljean A, Gurrell I, Webster C Isolation of blood-brain barrier-crossing antibodies from a phage display library by competitive elution and their ability to penetrate the central nervous system mAbs Journal 304-314 Link
01/06/2018 Wassmer T, Evans L, Fraser G, Smith J, Perkinton M, Billinton A, Livesey FJ Extracellular monomeric and aggregated tau efficiently enter human neurons through overlapping but distinct pathways Cell Reports 3624 Link
01/03/2018 Nicol LSC, Thornton P, Hatcher JP, Glover CP, Webster CI, Burrell M, Hammett K, Jones CA, Sleeman MA, Billinton A, Chessell I Central inhibition of granulocyte-macrophage colony-stimulating factor is analgesic in experimental neuropathic pain Pain 532 Link
11/04/2018 Scott IC, Majithiya JB, Sanden C, Thornton P, Sanders P, Moore T, Guscott M, Corkill DJ, Erjefalt JS, Cohen ES Interleukin-33 is activated by allergen- and necrosis-associated proteolytic activities to regulate its alarmin activity during epithelial damage Scientific Reports doi:10.1038/s41598-018-21589-2 Link
05/05/2018 Jaffe A, Straub R, Shin J, Tao R, Gao Y, Collado Torres L, Kam-Thong T, Xi S, Quan J, Colantuoni C, Ulrich B, Maher B, Deep-Soboslay A, Cross A, Brandon N, Leek J, Hyde T, Kleinman J, Weinberger D Development and genetic regulation of the human frontal cortex transcriptiome in schizophrenia Neuron doi:10.1038/nn.4181 Link
21/02/2018 Ye N, Monk SA, Daga P, Bender DM, Rosen LB, Mullen J, Minkwitz MC, Kugler AR Clinical bioavailability of the novel BACE1 inhibitor lanabecestat (AZD3293): Assessment of tablet formulations versus an oral solution and the impact of gastric pH on pharmacokinetics Clinical Pharmacology in Drug Development 233-243 Link
06/02/2014 Chen, K.-F. Possidente, B. Lomas, D. A. Crowther, D. C. The central molecular clock is robust in the face of behavioural arrhythmia in a Drosophila model of Alzheimer's disease Disease Models & Mechanisms 7(4), 445-458 Link
01/07/2017 Thornton, Peter Sevalle, Jean Deery, Mike J Fraser, Graham Zhou, Ye Ståhl, Sara Franssen, Elske H Dodd, Roger B Qamar, Seema Gomez Perez-Nievas, Beatriz Nicol, Louise Sc Eketjäll, Susanna Revell, Jefferson Jones, Clare Billinton, Andrew St George-Hyslop, Peter H Chessell, Iain Crowther, Damian C TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant EMBO molecular medicine e201707673 Link